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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In studies on superfused synaptosomes from the rat medulla oblongata, the inhibitory effects of theα2-adrenergic agonist clonidine (0.1μM) on potassium (15 mM K+) induced3H-noradrenaline (NA) release was potentiated by 20%, when neuropeptide Y was added to the system.”
Neuropeptide Y enhances the inhibitory effects of clonidine on3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat“The α agonists clonidine and phenylephrine both inhibited the potassium currents and elevated intracellular calcium levels.”
“This was … that clonidine … potassium conductance by causing an elevation in the free intracellular calcium concentration 7 Clonidine reversibly depressed the amplitude of the nicotinic fast excitatory … effects of clonidine were shared by adrenaline and the actions of both were reversed or prevented by phentolamine (100 nM‐1 μM).”
“4 The monovalent cations, sodium and potassium , and the divalent cation, calcium, produced concentration‐dependent decreases in [3H]‐clonidine binding to membranes prepared from renal cortex, the EC50s being respectively 25 mm, 37 mm and 23 mm.”
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