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Last Updated: 3 years ago

Possible Interaction: Clonidine and Niacin



Research Papers that Mention the Interaction

antagonised the gastroprotective effect of clonidine , it would appear that in the periphery nicotinic , but not muscarinic, cholinergic receptors are likely to be involved in the mucosal protective effect of clonidine.
Neuropharmacology  •  2000  |  View Paper
The antiallodynic effect produced by intrathecally administered clonidine was attenuated in a dose-dependent manner by intrathecal treatment with muscarinic and nicotinic antagonists.
Anesthesiology  •  1999  |  View Paper
These data are consistent with the hypothesis that clonidine inhibits nicotinic receptor-induced tyrosine hydroxylase phosphorylation by decreasing calcium influx into chromaffin cells, perhaps by an action at the nicotinic receptor.
Biochemical pharmacology  •  1996  |  View Paper
Only one set of observations has lent support to this suggestion: the rather specific alpha 2-adrenoceptor agonist clonidine inhibits catecholamine secretion evoked by the physiological secretagogue, acetylcholine, and by the related nicotinic agonists, carbachol and nicotine.
Molecular pharmacology  •  1986  |  View Paper
Both clonidine and noradrenaline reduced the nicotinic fast excitatory postsynaptic potential in a concentration dependent manner, although the maximum effect produced by noradrenaline was greater.
Neuroscience  •  1986  |  View Paper
This was true for both the hyperpolarization and the conductance increase … causing an elevation in the free intracellular calcium concentration 7 Clonidine … nicotinic fast excitatory postsynaptic potential and the noncholinergic slow excitatory postsynaptic potential 8 All … actions of both were reversed or prevented by phentolamine (100 nM‐1 μM).
British journal of pharmacology  •  1981  |  View Paper
In pretreated animals the antinicotinic as well as the sympathetic inhibitory actions of clonidine were significantly increased at a dosage of 30 micrograms/kg.
Arzneimittel-Forschung  •  1978  |  View Paper