Possible Interaction: Clonidine and Methionine

“Elimination half‐life of clonidine after removal of M was significantly greater than that after the final dosage of Catapres.”

“ Clonidine (3 × 10−9 to 3 × 10−7 M) blocked concentration‐dependently the contractile response to electrical field stimulation of human prostate and this inhibitory effect was reversed by yohimbine ( 10−7 M).”

“Plasma concentrations of clonidine increased after application of M in each trial.”

“These results suggest that the plasma concentrations of clonidine after application of M and its hypotensive effect are affected by the site of application in human subjects.”

“The noradrenaline curves were 4.5, 19 and 190-fold less potent after clonidine pretreatment at 10−5, 10−4 or 10−3 M for 10 min, respectively, added to Emax decrease by about 20%.”

“ Clonidine at concentrations of 10−5 and 10−4 M reduced the cyclic AMP content to below basal levels.”

“Pretreatment of the preparation with amiloride 10−3 M ), an inhibitor of Na+/H+ exchange, completely prevented the alkalinization and markedly reduced the potentiating effect of clonidine on the isoproterenol-induced respiratory rate.”

“ Clonidine at 1.50 × 10-7 M reduced the Vmax, but did not affect the Km of EAAT3 for L-glutamate.”