Possible Interaction: Clonidine and Melatonin

“RESULTS Administration of cl nidine si gnificantly reduced mel atonin co ncentrations in depressed patients but not in control subjects.”

“Also, the anxiolytic effect of melatonin and clonidine resulted in reduced postoperative morphine consumption by more than 30%.”

“ Clonidine , an α‐adrenoceptor agonist, reduces human plasma melatonin levels when administered intravenously at 2–3 (μg kg−1 to sleeping volunteers.”

“… clonidine … melatonin levels in human; some blind people appear to have free-running melatonin secretory circadian rhythms; bright light can acutely suppress human melatonin production according … acute suppressant effect (mainly in the evening during long photoperiods) and an entrainment effect (particularly during the morning but also in the evening).”

“AIMS We examined the nature of pharmacological interaction after coadministration of melatonin with clonidine or neostigmine on formalin-induced nociception at the spinal level.”

“Isobolographic analysis showed additivity between melatonin and clonidine or neostigmine in both phases.”

“ Melatonin (10 nM) reduced the efficacy, but not potency, of the contractile responses to methoxamine and clonidine.”

“In contrast, clonidine , an alpha-2 adrenergic receptor agonist, inhibited the nocturnal rise in pineal NAT activity and melatonin content although being without effect on these parameters in retina.”