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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clonidine
supplement:
Guanidines
Research Papers that Mention the Interaction
“The specific binding of [3H]clonidine to bovine adrenal medullary membranes was concentration-dependently inhibited by various imidazolines, guanidines and an oxazoline derivative but not, or with negligible affinity, by rauwolscine and (−)-adrenaline.”
Binding of [3H]clonidine to I1-imidazoline sites in bovine adrenal medullary membranes“… [3H]clonidine to rat stomach membranes … various imidazolines and guanidines including the sigma site ligand 1,2-di-(2-tolyl)guanidine (DTG), by the butyrophenone derivative haloperidol and by the …[(R)-3-(3-hydroxyphenyl)-N-propylpiperidine]; the latter two compounds are also known to exhibit affinity for sigma sites.”
“ Guanidine uptake was only minimally inhibited by organic cations such as tetraethylammonium, N1-methylnicotinamide, and choline, but many other organic cations such as amiloride, clonidine , imipramine, and harmaline caused considerable inhibition.”
“4-Aminopyridine, guanidine and tetraethylammonium blocked no-competitvely the binding of [3H]clonidine in brain membranes.”
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