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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clonidine
supplement:
Glutathione
Research Papers that Mention the Interaction
“As indicators of oxidative stress, clonidine induced a significant reduction in GSH and SOD levels as well as an increase lipid peroxidation level.”
Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: Impact on oxidative stress, inflammation, apoptosis and monoamine levels.“The increased osmotic fragility of erythrocytes and the elevation of plasma NE level in burned animals were markedly lowered by clonidine which also raised the glutathione level of whole blood and enhanced the activity of glutathione peroxidase.”
“ Clonidine , an alpha 2-adrenoreceptor stimulating agent, also depressed hepatic glutathione concentrations in a dose-dependent manner.”
“Since epinephrine and clonidine have been shown to decrease hepatic glutathione (GSH) by activating alpha 2-adrenoceptors, and alpha 2-antagonists partially antagonize GSH depletion and hepatotoxicity caused by bromobenzene and cocaine, we have investigated whether the formamidines would affect hepatic GSH levels in mice.”
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