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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Clonidine
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“ Clonidine inhibited the K(+)-evoked Glu overflow by 30-40% in the posterior cortex and hippocampus.”
“When clonidine (10(-4) M) was added to the perfusion medium, the K(+)-evoked overflow of both Asp and Glu was inhibited by 50-90% in the anterior cortex, thalamus and hypothalamus.”
Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions.“ Clonidine inhibited K(+)-evoked Glu and Asp overflow to 40 and 30% of the control with a potency (IC50) of 11 and 36 nM, respectively.”
“ Clonidine inhibited the K(+)-evoked overflow of Glu and Asp in a concentration-dependent manner, but the GABA overflow was not inhibited.”
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