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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clonidine
supplement:
Epinephrine
Research Papers that Mention the Interaction
“In 13 of the 15 patients who completed the study, pre-treatment with clonidine decreased plasma concentrations of noradrenaline, dopamine and adrenaline by 56, 15 and 25% respectively.”
Sympathetic suppression attenuates anomalous responses to morphine in unexplained pain after cholecystectomy“Conclusions: The admixture of clonidine to bupivacaine plus epinephrine prolongs and enhances brachial plexus blockade.”
“Implications: Clonidine , a commonly used preanesthetic medication, alters patients' cardiovascular responses to drugs such as epinephrine.”
“We conclude that premedication with clonidine enhances HR and BP responses to the IV administration of epinephrine-containing epidural test solutions.”
“ Clonidine reduced preoperative epinephrine and norepinephrine concentrations by 65%.”
“The duration and degree of motor block were increased by addition of both epinephrine and clonidine.”
“We conclude that coadministration of epinephrine or clonidine with meperidine enhances the duration and degree of spinal anesthesia and that adding clonidine prolongs the duration of postoperative analgesia. (”
“ Clonidine caused a significant suppression of plasma adrenaline , plasma noradrenaline, urinary noradrenaline excretion and mean arterial blood pressure.”
“ Clonidine significantly reduced the plasma levels of epinephrine (P = 0.009) and norepinephrine (P = 0.026) measured on the first postoperative morning.”
“Noradrenaline, adrenaline and vasopressin concentrations decreased in the clonidine group throughout recovery (P less than 0.001, 0.05 and 0.05, respectively, vs placebo).”
“Adding 0.15 mg clonidine or 0.4 mg adrenaline significantly prolonged mean times for two- and four-segment regression and mean times for regression to L2 level.”
“Basal BP was similar in the two groups, but clonidine decreased BP, PRA, and plasma epinephrine more in responders than in nonresponders.”
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