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Last Updated: 3 years ago

Possible Interaction: Clonidine and Epinephrine



Research Papers that Mention the Interaction

In 13 of the 15 patients who completed the study, pre-treatment with clonidine decreased plasma concentrations of noradrenaline, dopamine and adrenaline by 56, 15 and 25% respectively.
Clinical Autonomic Research  •  2005  |  View Paper
Conclusions: The admixture of clonidine to bupivacaine plus epinephrine prolongs and enhances brachial plexus blockade.
European journal of anaesthesiology  •  2004  |  View Paper
Implications: Clonidine , a commonly used preanesthetic medication, alters patients' cardiovascular responses to drugs such as epinephrine.
We conclude that premedication with clonidine enhances HR and BP responses to the IV administration of epinephrine-containing epidural test solutions.
Anesthesia and analgesia  •  1998  |  View Paper
Clonidine reduced preoperative epinephrine and norepinephrine concentrations by 65%.
Critical care medicine  •  1997  |  View Paper
The duration and degree of motor block were increased by addition of both epinephrine and clonidine.
We conclude that coadministration of epinephrine or clonidine with meperidine enhances the duration and degree of spinal anesthesia and that adding clonidine prolongs the duration of postoperative analgesia. (
Anesthesia and analgesia  •  1997  |  View Paper
Clonidine caused a significant suppression of plasma adrenaline , plasma noradrenaline, urinary noradrenaline excretion and mean arterial blood pressure.
Acta physiologica Scandinavica  •  1996  |  View Paper
Clonidine significantly reduced the plasma levels of epinephrine (P = 0.009) and norepinephrine (P = 0.026) measured on the first postoperative morning.
Anesthesia and analgesia  •  1994  |  View Paper
Noradrenaline, adrenaline and vasopressin concentrations decreased in the clonidine group throughout recovery (P less than 0.001, 0.05 and 0.05, respectively, vs placebo).
British journal of anaesthesia  •  1991  |  View Paper
Adding 0.15 mg clonidine or 0.4 mg adrenaline significantly prolonged mean times for two- and four-segment regression and mean times for regression to L2 level.
Annales francaises d'anesthesie et de reanimation  •  1988  |  View Paper
Basal BP was similar in the two groups, but clonidine decreased BP, PRA, and plasma epinephrine more in responders than in nonresponders.
Circulation  •  1984  |  View Paper
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