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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Clonidine
supplement:
Dextroamphetamine
Research Papers that Mention the Interaction
“A 9-year-old taking clonidine and dextroamphetamine developed psychosis, abnormal involuntary movements, and insomnia.”
Dyskinesias associated with atomoxetine in combination with other psychoactive drugs“ Clonidine (0.1 mg every 8 hours) and guanfacine (1 mg every 8 hours) while on dextroamphetamine reduced tics by 50 %, but this was still unacceptable to the patient.”
“ D-amphetamine and yohimbine decreased N1 latency and clonidine increased it.”
“In self-stimulation behavior, clonidine decreases responding and blocks the facilitation caused by d-amphetamine.”
Effect of clonidine on the noradrenergic cyclic AMP generating system in the limbic forebrain and on medial forebrain bundle self-stimulation behavior“In the mouse, central noradrenaline receptor stimulation by clonidine , or intracerebroventricular injection of noradrenaline or α-methylnoradrenaline, caused marked enhancement of the locomotor stimulant effects of dexamphetamine in doses that were without effect when given alone.”
“Noradrenaline and alpha-methyl noradrenaline intracerebroventricularly (ICV), and clonidine IP, all tended to reduce control SRA but potentiated the effect of d-amphetamine.”
“ResultsThe psychomotor stimulant effect of d-amphetamine , but not that of cocaine or apomorphine, was dose-dependently inhibited by clonidine and prazosin, and enhanced by propranolol.”
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