Possible Interaction: Clonidine and Cocaine

“OBJECTIVE The authors tested whether clonidine blocks stress-induced seeking of heroin and cocaine.”

“ Clonidine significantly attenuated the previously established cocaine place preference when tested 1 or 7 days later.”

“ Clonidine , an α2 noradrenergic receptor agonist, was tested for its ability to block reconsolidation of cocaine environmental-paired memory.”

“These results suggest that clonidine can interfere with reconsolidation of cocaine memory and may be a useful approach to reduce relapse.”

“Secondary or tertiary amine CNS compounds such as oxycodone, morphine, diacetylmorphine, methylenedioxyamphetamine (MDMA), cocaine , and nicotine inhibited Clonidine transport.”

“While both Clonidine and 8-OHDPAT can substantially attenuate a number of cocaine behavioral effects, these inhibitory effects appear to be secondary to reductions in the behavioral baseline rather than reversals of cocaine effects.”

“Sensitization to the effects of morphine and cocaine were significantly reduced in monkeys previously treated with clonidine.”

“The priming effects of cocaine were antagonized by clonidine and flupenthixol.”

“The alpha‐2 agonist clonidine attenuated the acute response to cocaine on day 1 and retarded the increased locomotor activity on the following 2 days.”

“The influences of cocaine, DU 24565 and maprotiline on the effect … their ability to inhibit 3H-serotonin accumulation: The inhibitory effect of clonidine … cocaine (which inhibited both 3H-serotonin and 3H-noradrenaline accumulation) and DU 24565 (which …) but was not changed by maprotiline (which selectively blocked 3H-noradrenaline accumulation).”

“With clonidine the pre-cocaine MAP was lower and the hypertensive effect of cocaine was blocked by 50%, indicating an important role for central alpha-adrenergic mechanisms.”

“Subjects exposed to the 40 mg/kg dose of cocaine demonstrated an enhanced sensitivity to the locomotor stimulating effects of clonidine relative to both control groups.”