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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clonidine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“When the Ca++ responses are compared to the previously published results on cAMP inhibition in Chinese hamster ovary cells, clonidine seems to be significantly less efficacious in elevating Ca++ than in decreasing cAMP.”
Ligand- and subtype-selective coupling of human alpha-2 adrenoceptors to Ca++ elevation in Chinese hamster ovary cells.“ Clonidine also inhibited both cAMP and Ca2+ -induced decreases in apical Na+ uptake and apical membrane NHE2 and NHE3 endocytosis stimulated by these agents.”
“UK 14,304 and Clonidine at 10 microM significantly induced an increase in intracellular calcium concentration.”
[Signal transduction of serotonin release from enterochromaffin cells in mouse ileal crypts].“ Clonidine also increases the basal phosphorylation of tyrosine hydroxylase at Ser-19, perhaps by directly activating calcium and calmodulin-stimulated protein kinase II.”
“ Clonidine inhibited the uptake of calcium and the overall phosphorylation of tyrosine hydroxylase induced by nicotinic receptor activation in bovine adrenal medullary chromaffin cells in culture.”
“ Low-Ca2+ solutions also blunted but did not block entirely the clonidine response, indicating that the primary Ca2+ release was from intracellular stores.”
“A single, high dose of clonidine followed by an overnight fast caused marked increases in calcium content and acinar secretory granules in the submandibular and sublingual glands, similar to those caused by reserpine.”
“This inward Ca current was also blocked by 2‐5 microM‐clonidine in the bath.”
“With clonidine , the volume of submandibular saliva was much higher but the Ca concentration was 3-4 times lower than that of the parotid; both salivas had low Na but high K concentrations.”
“Stimulation of alpha 2-adrenoceptors or kappa-opiate receptors with clonidine (0.1-100 microM) or dynorphin A fragment (1-13) (0.2-5.0 microM) respectively, produced a dose dependent reduction in the intrasynaptosomal free calcium concentration.”
“ Clonidine (5 microM) significantly reduced trifluoperazine-induced release by approximately 50% in the presence of Ca++ , and in its absence, clonidine significantly attenuated the trifluoperazine response by 42%.”
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