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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clonidine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“In treated horses but not controls, the ratio between the secretion rates of ACTH and AVP fell (P = 0.009), while the ACTH : CRH ratio tended to fall after clonidine , implying reduced responsiveness to stimulation.”
“Secretion rates of ACTH (P = 0.008) and AVP (P = 0.0005) fell after clonidine and remained lower than baseline values for 20 min and 10 min, respectively.”
The Effect of the Alpha‐2‐Adrenergic Agonist, Clonidine, on Secretion Patterns and Rates of Adrenocorticotropic Hormone and its Secretagogues in the Horse“We used the α2‐adrenergic agonist, clonidine , as a central nervous system inhibitor of ACTH release to see if it would alter naloxone‐induced ACTH secretion in normal human volunteers.”
“In Cushing's disease, ACTH significantly decreased in response to clonidine.”
“… clonidine (0.225 mg) in one dose significantly lowered … reduced the plasma level of beta EpLI and ACTH , while the placebo had no effect on blood pressure, heart rate or plasma level of beta …-endorphin does not play a major role in the antihypertensive action of acute clonidine administration.”
“We have previously reported a decrease in cortisol levels in prepubertal children following administration of clonidine 2 ; however, in a group of healthy adults 3 we found a decrease of both corticotropin and cortisol concentrations following oral administration of 150 μg of clonidine at”
“ Clonidine at 9 sites in an area that included the ventrorostral LC inhibited ACTH (P less than 0.05), and yohimbine at 7 sites within this latter area facilitated ACTH (P less than 0.01).”
Alpha-adrenergic input in the locus coeruleus modulates plasma adrenocorticotropin in cats.“injection of clonidine (alpha 2 agonist; 1 nmol) induced a 3 fold rise of ACTH release (measured by RIA) above vehicle (PBS) injected controls (p less than 0.001).”
“Administration of the alpha-2 agonist clonidine resulted in a 24-fold increase in plasma adrenocorticotropin and a significant decrease in median eminence corticotropin-releasing factor, consistent with its release.”
“Epinephrine, norepinephrine, phenylephrine, clonidine , B-HT933, and B-HT920 caused a significant and dose-related increase of the ACTH concentration in the serum.”
“In rats with complete deafferentation of the medial basal hypothalamus (MBH), ACTH secretion induced by epinephrine, norepinephrine, and clonidine was significantly blocked, as compared with intact rats.”
“Norepinephrine, epinephrine and clonidine , but not methoxamine and phenylephrine inhibited ACTH secretion.”
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