Possible Interaction: Clonazepam and Gamma-Aminobutyric Acid

“ Clonazepam , effective in open case studies, potentiates, through unknown mechanisms, the neurotransmitter gamma-aminobutyric acid (GABA).”

“Coapplication of the benzodiazepine clonazepam and 10 microM GABA augmented the amplitude of the GABA response.”

“Baclofen and, to lesser degree, clonazepam showed noticeable results, most likely due to their influence on the γ-aminobutyric acid system and, hence, suppression of glutamate release.”

“In burning mouth patients, analgesia after oral administration of clonazepam may result from modulation of peripheral γ‐aminobutyric acid (GABA) receptors.”

“ Clonazepam and diazepam enhance the inhibitory action of GABA , decrease inhibition in neuronal networks and affect calcium ion transport with lesser effects on repetitive firing.”

“Augmentation of GABA responses by the benzodiazepine, clonazepam (CNZ), was significantly reduced in RE in comparison to control neurons (34% vs 99% augmentation at 100 nM).”

“with phenobarbital (10 mg/kg) and clonazepam (0.5 mg/kg) significantly reversed seizure-induced changes in aspartate and GABA concentrations while valproate (300 mg/kg) significantly reduced aspartate concentrations further.”

“Modulation of GABA responses by the benzodiazepine, clonazepam , was significantly reduced in epileptic neurons compared with controls.”

“Bath-applied CZP reduced the gamma-aminobutyric acid-B (GABAB) component of inhibitory postsynaptic potentials and currents (IPSPs and IPSCs, respectively) evoked in rat thalamic somatosensory relay neurons by stimulation of nucleus reticularis thalami (nRt), without consistently affecting the GABAA IPSP.”

“Dry autoradiography showed 3H‐PNZ binding only in the inner plexiform layer (IPL); the binding was enhanced with γ‐aminobutyric acid GABA ) and blocked by clonazepam.”