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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Clomipramine
supplement:
Tryptophan
Research Papers that Mention the Interaction
“ Clomipramine is particularly well suited for the treatment of resistant depression, for which its efficacy may be enhanced by combination therapy with tryptophan and/or lithium.”
Worldwide use of clomipramine.“Oral administration of 20 mg clomipramine 2 h prior to LTP infusion (50 mg/kg) significantly enhanced both endocrine responses, suggesting that the increases in plasma PRL and GH produced by LTP are mediated by 5-HT pathways.”
“ Tryptophan (TRP) levels in the three brain areas were significantly increased with clomipramine and fluoxetine but not with moclobemide.”
Differential changes in brain and platelet 5-HT concentrations after steady-state achievement and repeated administration of antidepressant drugs in mice“This study was performed to investigate if the antidepressant agents amitriptyline and clomipramine could, by such a mechanism, increase brain concentrations of administered tryptophan.”
“It was found that imipramine and particularly chlorimipramine potentiated the effects of 5-hydroxytryptophan, tryptophan and nialamide on the extensor hindlimb reflex.”
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