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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Clomipramine and Tryptophan



Research Papers that Mention the Interaction

Clomipramine is particularly well suited for the treatment of resistant depression, for which its efficacy may be enhanced by combination therapy with tryptophan and/or lithium.
The Journal of clinical psychiatry  •  1990  |  View Paper
Oral administration of 20 mg clomipramine 2 h prior to LTP infusion (50 mg/kg) significantly enhanced both endocrine responses, suggesting that the increases in plasma PRL and GH produced by LTP are mediated by 5-HT pathways.
Psychopharmacology  •  2004  |  View Paper
Tryptophan (TRP) levels in the three brain areas were significantly increased with clomipramine and fluoxetine but not with moclobemide.
European Neuropsychopharmacology  •  1999  |  View Paper
This study was performed to investigate if the antidepressant agents amitriptyline and clomipramine could, by such a mechanism, increase brain concentrations of administered tryptophan.
The Journal of pharmacy and pharmacology  •  1998  |  View Paper
It was found that imipramine and particularly chlorimipramine potentiated the effects of 5-hydroxytryptophan, tryptophan and nialamide on the extensor hindlimb reflex.
European journal of pharmacology  •  1970  |  View Paper