Possible Interaction: Clomiphene and Progesterone

“CONCLUSIONS Cl miphene an d possibly pro gesterone ma y increase thyroid cancer risk, particularly among parous women.”

“Also, the midluteal concentrations of estradiol and progesterone in the clomiphene cycle were significantly higher (P less than 0.005 and P less than 0.005, respectively) than those in the nontreatment cycle.”

“Both Clomiphene and Epimestrol treatments led towards higher plasma progesterone levels, those following Clomiphene administration being higher.”

“It is concluded that Clomiphene induces significant elevations of CBG and decrease in salivary progesterone , which is thought to reflect the free progesterone fraction and may have significance in relation to a discrepancy between the ovulation and pregnancy rates following Clomiphene therapy.”

“The serum levels of estradiol-17 beta and progesterone in a cycle which was hyperstimulated by Clomiphen are reported.”

“Response values in our normal group suggested that higher progesterone levels need to be reached after clomiphene administration than in spontaneous cycles for ovulation to be inferred.”

“Increased clomiphene dosage resulted in higher plasma oestradiol and progesterone levels.”

“From the influence of progesterone alone and the combined influence of progesterone and clomiphene on the LH and FSH levels in the plasma it was deduced that the cycle-lengthening effect of progesterone was due to a short-lasting depletion of pituitary LH.”

“The dose-dependent effect of clomiphene was much more pronounced on follicles cultured with LH; while 0.01 mM had no effect, 2 mM clomiphene decreased progesterone accumulation by 97%, estradiol-17 beta by 90% and testosterone by 65% (P less than 0.001).”

“The results indicate that progesterone does have a significant interaction with clomiphene in the control of uterine morphology and biochemistry.”

“Serum Estradiol & Progesterone levels were statistically significantly higher in clomiphene and laser treated groups than non-interventional controls, while no significant difference between clomiphene and laser groups as regard of both hormones.”