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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clofibrate
supplement:
NADH
Research Papers that Mention the Interaction
“Hepatic NAD+, NADH , and NADPH were increased significantly 3 days after feeding rats with a 0.25% clofibrate diet , increased further after 8 days, and stayed at the same levels 14 days after feeding the diet.”
Pyridine nucleotide levels in liver of rats fed clofibrate- or pyrazinamide-containing diets.“ Clofibrate also promoted a decrease in serum cholesterol and triacylglycerol levels, delta 6 desaturase activity and a suppression of the electron transport chain as measured by NADH cytochrome b5 reductase and NADH cytochrome c reductase.”
“ Clofibrate interfered with the integrity of the mitochondrial membranes, since it stimulated ATPase activity and increased the normally low permeability of intact mitochondria toward NADH.”
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