Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Clofibrate and NADH



Research Papers that Mention the Interaction

Hepatic NAD+, NADH , and NADPH were increased significantly 3 days after feeding rats with a 0.25% clofibrate diet , increased further after 8 days, and stayed at the same levels 14 days after feeding the diet.
Biochemical pharmacology  •  1998  |  View Paper
Clofibrate also promoted a decrease in serum cholesterol and triacylglycerol levels, delta 6 desaturase activity and a suppression of the electron transport chain as measured by NADH cytochrome b5 reductase and NADH cytochrome c reductase.
Acta physiologica latino americana  •  1981  |  View Paper
Clofibrate interfered with the integrity of the mitochondrial membranes, since it stimulated ATPase activity and increased the normally low permeability of intact mitochondria toward NADH.
Biochemical pharmacology  •  1974  |  View Paper