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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clofibrate
supplement:
Glutathione
Research Papers that Mention the Interaction
“ CFB pretreatment significantly enhanced the levels of superoxide dismutase (SOD) and glutathione (GSH), and markedly decreased the malonaldehyde (MDA) content.”
Protective effect of coptisine free base on indomethacin‐induced gastric ulcers in rats: Characterization of potential molecular mechanisms“Repeated treatment with clofibrate (CFB) significantly increased hepatic glutathione (GSH) content and also diminished acetaminophen's (APAP) selective protein arylation, GSH depletion, and severity of hepatocellular necrosis.”
“At 4 hr after APAP treatment, hepatic glutathione (GSH) depletion and selective arylation of the major APAP target proteins were both greatly diminished by CFB pretreatment.”
“Pretreatment with CFB also produced a significant elevation in hepatic GSH.”
“ Clofibrate administration produced decrease in gamma-glutamyltranspeptidase (GGT) activity with concomitant increase in glutathione concentration.”
“ CLOF induced a low incidence of GSH positive foci; nodules showed universally lower levels of catalase and GSH.”
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