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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clofibrate
supplement:
Epinephrine
Research Papers that Mention the Interaction
“… clofibrate has been shown … thrombin, ADP and epinephrine , by blocking the release of arachidonic acid from platelet phospholipids [8], here we have demonstrated that clofibrate enhanced platelet aggregation by … effects of PGE1 on platelet cAMP concentration and on PLC-induced secretion of [14C]-5HT in similar, concentration-dependent manners.”
Potentiating effects of clofibrate on prostaglandin-dependent and -independent pathways of human platelet activation: evidence for involvement of cyclic AMP.“Abstract The hypolipidemic drugs halofenate and clofibrate inhibit the aggregation of human platelets induced by ADP, collagen and epinephrine.”
“The effect on the release was probably mediated through decreased platelet sensitivity since higher doses of epinephrine could reverse the inhibitory effect of clofibrate.”
“ Clofibrate decreased these responses to both insulin and epinephrine.”
“ Clofibrate may act at the plasma membrane of the adipose cell to inhibit the lipolytic effects of epinephrine and the antilipolytic effects of insulin.”
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