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Last Updated: 3 months ago

Possible Interaction: Clofibrate and Cocoa Extract

supplement:

Cocoa Extract

Research Papers that Mention the Interaction

When the concentration of one of the substrates, procainamide, is 100 microM while the other, acetyl CoA , is 10 or 100 microM, the specific activity is reduced following clofibrate treatment.
General pharmacology  •  1989  |  View Paper
It is therefore evident that clofibrate affects the CoA concentration by increasing the rate of synthesis, although the rate of CoA degradation is simultaneously decreased, as has been shown previously [9].
Biochemical pharmacology  •  1980  |  View Paper
These rates of CoA degradation indicate that the effect of clofibrate on CoA concentration may be mainly due to inhibition of the enzymes of CoA degradation, although recycling of the label cannot be excluded.
The Biochemical journal  •  1979  |  View Paper
1 The amounts of CoA in rat liver increased about three fold after treatment with clofibrate.
European journal of biochemistry  •  1979  |  View Paper