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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Clofazimine and Vitamin K

supplement:

Vitamin K

Research Papers that Mention the Interaction

CZM presumably competes with menaquinone (MK-4), a key cofactor in the mycobacterial electron transfer chain, for its reduction by NDH-2.
We studied the effect of MK-4 supplementation on the activity of CZM against M. tuberculosis and found direct competition between CZM and MK-4 for the cidal effect of CZM, against nonreplicating and actively growing bacteria, as MK-4 supplementation blocked the drug's activity against nonreplicating bacteria.
Antimicrobial Agents and Chemotherapy  •  2015  |  View Paper