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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Clofazimine and Vitamin E

supplement:

Vitamin E

Research Papers that Mention the Interaction

However, alpha-tocopherol , a lysophospholipid-complexing agent, completely blocked the antiproliferative effects of the riminophenazines and also protected the cells against the direct cytotoxic effect of lysophosphatidylcholine, while the lysophospholipid-neutralizing enzyme lysophospholipase protected against the riminophenazines.
Cancer research  •  1993  |  View Paper
Inclusion of the extracellular and intracellular Ca2+-chelating agents EGTA (0.2-7.2 g/L) and BAPTA/FURA-2 (…), individually or in combination, did not prevent the effects of B669 on mycobacterial PLA2 activity or K+ transport, whereas alpha-tocopherol , which neutralizes PLA2 … effects of the riminophenazines on ….
The Journal of antimicrobial chemotherapy  •  1999  |  View Paper
Addition of reagent AA and especially LPC to neutrophils mimicked the effects of the riminophenazines, while alpha-tocopherol , a lysophospholipid complex-forming agent, neutralized the prooxidative interactions of clofazimine and B669 with these cells.
The Journal of infectious diseases  •  1993  |  View Paper
The inhibitory effects of both riminophenazines on the Na+, K+-ATPase activity of FaDu cells were mimicked by reagent LPC and prevented by treatment of the cells with the lysophospholipid-neutralizing agents alpha-tocopherol and lysophospholipase.
International journal of oncology  •  1994  |  View Paper