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Discover Supplement-Drug Interactions

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Last Updated: 5 days ago

Possible Interaction: Clofarabine and Sulforaphane



Research Papers that Mention the Interaction

In the present study, using methylation-sensitive restriction analysis (MSRA) and qPCR, we showed that clofarabine in combination with sulforaphane , a phytochemical from cruciferous vegetables, significantly reactivates DNA methylation-silenced CDKN2A tumour suppressor and inhibits cancer cell growth at a non-invasive breast cancer stage.
Nucleosides, nucleotides & nucleic acids  •  2018  |  View Paper
Conclusions: Our findings provide evidence that SFN activates DNA methylation-silenced tumour suppressor genes in breast cancer cells and may contribute to SFN-mediated support of therapy with an anti-cancer drug, ClF , increasing its applications in solid tumours.
The combination of SFN and ClF enhances these effects, resulting in an increase in cell growth arrest and apoptosis at a non-invasive breast cancer stage.
Lifestyle Genomics  •  2015  |  View Paper