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Discover Supplement-Drug Interactions

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Last Updated: 24 days ago

Possible Interaction: Clodronic Acid and Calcium Supplement

Research Papers that Mention the Interaction

Unlike the controls, the patients who received CL2MDP presented a significant reduction in urinary calcium (p = 0.003) and in hydroxyproline (p = 0.05) on the 7th day.
Oncology  •  1991  |  View Paper
Of the 12 patients who received Cl2MDP (2 died in the placebo phase), 11 had marked reductions in urinary calcium (P less than 0.001), which fell into the normal range in 9.
Bone  •  1987  |  View Paper
Two patients died during the placebo phase; of eight patients who received Cl2MDP , seven had rapid, sustained, and highly significant (P less than 0.001) decreases in urinary excretion of calcium.
The New England journal of medicine  •  1980  |  View Paper
Cl2MDP (800–3200 mg daily by mouth or 300 mg daily by intravenous infusion) decreased plasma calcium and biochemical indices of increased bone resorption in 16 of 19 patients.
British journal of haematology  •  1983  |  View Paper
In two of these patients there was a response to retreatment with Cl2MDP with a fall in calcium from 16.9 +/- 0.5 mg/dl to 12.4 +/- 1.5 mg/dl.
The American journal of medicine  •  1982  |  View Paper
Bone fat-free weight, fat-free minus ash weight, and bone calcium and phosphorus concentration were reduced significantly in rats given 10 mg/kg Cl2MDP compared to controls.
Calcified Tissue Research  •  2005  |  View Paper