Possible Interaction: Clodronate and Calcium Supplement

“Doses of ≥1,600 mg clodronate produced mean reductions of >40% in U-NTX, S-CTX and U-Ca , all significantly different from placebo (P = 0.0015, 0.001, 0.0036, respectively), after 6 weeks.”

“These results indicate that clodronate is transported paracellularly through Caco-2 cells and that calcium decreases strongly its absorption.”

“Although clodronate is less potent than EDTA in depleting calcium from the intestinal tissue, it significantly increased the paracellular permeability of viable rat jejunum "in vitro" when tested at 15 mM and higher concentrations (the highest therapeutic dose dissolved in 250 ml gives a 22 mM solution of clodronate).”

“ Calcium and/or iron have been suggested to be involved in the intracellular uptake and action of clodronate in phagocytic cells.”

“Free and esterified cholesterol and total Ca++ concentrations in the wall of thoracic aorta were reduced by the greatest dose of clodronate , compared with the groups treated with saline solution or smaller doses of the drug (p < 0.05).”

“The L‐type Ca2+ channel blocking drugs, nicardipine (10 nM) and verapamil (1 μM), reduced the second component of the norepinephrine‐mediated vasoconstriction, but in the presence of clodronate (20 μM) this blocking action was prevented.”