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Discover Supplement-Drug Interactions

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Last Updated: 24 days ago

Possible Interaction: Clodronate and Calcium Supplement

Research Papers that Mention the Interaction

Doses of ≥1,600 mg clodronate produced mean reductions of >40% in U-NTX, S-CTX and U-Ca , all significantly different from placebo (P = 0.0015, 0.001, 0.0036, respectively), after 6 weeks.
Calcified Tissue International  •  2007  |  View Paper
These results indicate that clodronate is transported paracellularly through Caco-2 cells and that calcium decreases strongly its absorption.
International journal of pharmaceutics  •  2001  |  View Paper
Although clodronate is less potent than EDTA in depleting calcium from the intestinal tissue, it significantly increased the paracellular permeability of viable rat jejunum "in vitro" when tested at 15 mM and higher concentrations (the highest therapeutic dose dissolved in 250 ml gives a 22 mM solution of clodronate).
Biological & pharmaceutical bulletin  •  2005  |  View Paper
Calcium and/or iron have been suggested to be involved in the intracellular uptake and action of clodronate in phagocytic cells.
Calcified Tissue International  •  2005  |  View Paper
Free and esterified cholesterol and total Ca++ concentrations in the wall of thoracic aorta were reduced by the greatest dose of clodronate , compared with the groups treated with saline solution or smaller doses of the drug (p < 0.05).
The Journal of laboratory and clinical medicine  •  1994  |  View Paper
The L‐type Ca2+ channel blocking drugs, nicardipine (10 nM) and verapamil (1 μM), reduced the second component of the norepinephrine‐mediated vasoconstriction, but in the presence of clodronate (20 μM) this blocking action was prevented.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1991  |  View Paper