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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clioquinol
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Here we show that clioquinol inhibits the activity of mammalian CLK-1 in cultured cells, an inhibition that can be blocked by iron or cobalt cations, suggesting that chelation is involved in the mechanism of action of clioquinol on CLK-1.”
The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1*“The authors then show that treatment with clioquinol CQ ), an antimicrobial agent with unique iron chelating properties, suppresses the increased iron accumulation that occurs in cells and in lung tissue duringexperimental IPF.”
“ Clioquinol increased the intracellular contents of iron and zinc as well as calcium as measured by ICP-AES.”
“We found that CQ could remarkably improve the motor and non-motor deficits, which were based on the reduction of iron content and ROS level in the SN and further improvement in pathology.”
Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway“Metallomic analysis revealed, however, that CQ reduced potassium and magnesium levels in the brain MEF and also lowered brain iron levels.”
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