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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clindamycin
supplement:
Quinine
Research Papers that Mention the Interaction
“Thus, the combination of clindamycin with chloroquine or quinine enhances parasite clearance and improves response to therapy.”
Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon.“Based on multiple case reports, a 7- to 10-day course of clindamycin plus quinine is often used to treat severe babesiosis.”
“Parasitemia increased from 2% up to 21% within 24 h under quinine (10 mg/kg) and clindamycin (450 mg/8 h) combination treatment.”
“ Clindamycin … quinine significantly reduced the risk of day 28 treatment failure compared with quinine (RR 0.14 [95% CI 0.07 to 0.29]), quinine plus … 0.57 [95% CI 0.26 to 1.24]), or chloroquine plus clindamycin (RR 0.38 [95% CI 0.13 to 1.10]).”
“ Quinine and clindamycin had an additive effect against NF54 but potentiated against K1.”
Evaluation of the sensitivity in vitro of Plasmodium falciparum and in vivo of Plasmodium chabaudi Malaria to various drugs and their combinations.“ Clindamycin plus quinine was also effective but less so than atovaquone.”
“The combination of quinine plus a fixed concentration of clindamycin (0.1 microgram/ml) inhibited growth of the quinine-resistant Indochina I strain, although most of the antiplasmodial activity observed at quinine concentrations less than 50 ng/ml (154 nM) could be attributed to clindamycin alone.”
Clindamycin activity against chloroquine-resistant Plasmodium falciparum.
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