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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clindamycin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“An increase in acetylcholine concentration caused by neostigmine and calcium may enhance the use-dependent ion channel block of the nicotinic acetylcholine receptor caused by clindamycin.”
“Neostigmine and calcium antagonized the neuromuscular blockade caused by gentamicin, but augmented that caused by clindamycin.”
“The effective concentration of 50% maximal effect (EC50) values of clindamycin for tetanic fade in the presence of 5 mM calcium or 250 nM neostigmine were reduced by approximately 52%.ConclusionClindamycin and gentamicin interfere with neuromuscular transmission and cause tetanic fade.”
Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations“The authors conclude that the administration of clindamycin may augment nondepolarizing blockade in man, and antagonism by neostigmine and calcium may be incomplete.”
“With 15 to 20 per cent depression of twitch tension by clindamycin , neostigmine (5-20 ng/ml) or calcium (81 mug/ml) slightly but not completely antagonized the blockade.”
“Neostigmine and calcium antagonize the neuromuscular blockade caused by gentamicin, but augment that caused by clindamycin [3].”
Antibiotics and muscle relaxation
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