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“ CLA derivatives increased the levels of intracellular calcium ions , caspase-3/7 and the percentage of sub-G1 apoptotic cells and blocked cells in the S phase of the cell cycle to a greater extent than free CLA.”
“Both the hydrolytic and the reverse activities of CDase were stimulated by calcium with an affinity constant (Ka) of 1.5 μM. Kinetics studies showed that calcium caused a decrease of Km and an increase in Vmax of pCDase.”