“Co-treatment with L-citrulline and BH4 more effectively improves NO signaling and inhibits chronic hypoxia-induced PH than either treatment alone.”
“Notably, greater improvements in PVR, eNOS dimer-to-monomer ratios, and NO production were found in hypoxic piglets co-treated with L-citrulline and BH4 than in piglets treated with either alone.”