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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Citrulline
drug:
Serotonin
Research Papers that Mention the Interaction
“A 2-day treatment with Cit or Cit + SB increased 5-HT release in both VTA and NAcc.”
“Acutely administered Cit + SB increased 5-HT release in the NAcc more than Cit alone.”
Serotonin-2C antagonism augments the effect of citalopram on serotonin and dopamine levels in the ventral tegmental area and nucleus accumbens“These data suggest that the administration of CIT reduces anxiogenic components and increases anxiolytic components of the CRF system in the midbrain serotonin network, which in turn leads to improved ovarian function.”
“A dose-response relationship of the inhibitory effect of CIT on the firing activity of 5-HT neurons was obtained with an ED50 of 0.23±0.03 mg/kg.”
“It is concluded that long-term CIT treatment enhances 5-HT neurotransmission by desensitizing both the somatodendritic and terminal 5-HT autoreceptors.”
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