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Last Updated: 2 years ago

Possible Interaction: Citrulline and Serotonin

supplement:

Citrulline

Research Papers that Mention the Interaction

A 2-day treatment with Cit or Cit + SB increased 5-HT release in both VTA and NAcc.
Acutely administered Cit + SB increased 5-HT release in the NAcc more than Cit alone.
Neurochemistry International  •  2015  |  View Paper
These data suggest that the administration of CIT reduces anxiogenic components and increases anxiolytic components of the CRF system in the midbrain serotonin network, which in turn leads to improved ovarian function.
Reproductive Sciences  •  2012  |  View Paper
A dose-response relationship of the inhibitory effect of CIT on the firing activity of 5-HT neurons was obtained with an ED50 of 0.23±0.03 mg/kg.
It is concluded that long-term CIT treatment enhances 5-HT neurotransmission by desensitizing both the somatodendritic and terminal 5-HT autoreceptors.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper