Possible Interaction: Citrulline and Omega-N-Methylarginine

“The presence of the arginine analogue NG‐methyl‐l‐arginine reduced citrulline production dose‐dependently but augmented DNA synthesis, both induced by LDL.”

“Demonstration of nitric oxide synthase activity in the Rachmilewitz study depends upon the inhibitory effect of monomethyl-Larginine (incorrectly labelled L-NAME in their paper) on the formation of " 4C citrulline , which was estimated from the scintillant activity of the Dowex elute thought to arise from citrulline alone.”

“Demonstration of nitric oxide synthase activity in the Rachmilewitz study depends upon the inhibitory effect of monomethyl-Larginine (incorrectly labelled L-NAME in their paper) on the formation of " 4C citrulline , which was estimated from the scintillant activity of the Dowex elute thought to arise from citrulline alone.”

“Incubation of biopsy samples from patients with ulcerative colitis with NG-monomethyl-L-arginine (L-NMMA) inhibited citrulline production.”

“ L-citrulline also stimulated NO production in HIT cells, which was inhibited by NMMA.”

“ N(G)-monomethyl-L-arginine (0.1 mmol/L), an inhibitor of nitric … synthase, inhibited the conversion of arginine to citrulline by these cells, blocked insulin-stimulated cGMP production, and blocked the inhibition by insulin of 5-hydroxytryptamine (5-HT)-stimulated Mn+2 (a Ca2+ surrogate) influx and contraction.”

“In vitro production of nitrite/nitrate and citrulline by cells and whole sponges was inhibitable by NMMA.”

“On the other hand, 1 mM NG-monomethyl-L-arginine (L-NMMA) (n = 6) evoked a persistent increase in both ARG and CIT.”

“ Citrulline and NO2-/NO3- levels in the supernatants of rat SPL MLC are decreased in the presence of NMA compared with cultures without NMA.”

“Inhibition of the L-arginine-dependent pathway by addition of NG-monomethyl-L-arginine (methyl group on a terminal guanidino nitrogen) inhibits the production of nitrite, nitrate, citrulline , and the g = 2.039 signal.”