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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Citrulline
drug:
Nitroarginine
Research Papers that Mention the Interaction
“The addition of L-citrulline (1 mM) added before L-NNA was without effect on the relaxant responses to field stimulation but was able to prevent the inhibition produced by L-NNA.”
“The inhibition produced by L-NNA was reversed by either L-arginine or L-citrulline.”
L-citrulline reverses the inhibition of nonadrenergic, noncholinergic relaxations produced by nitric oxide synthase inhibitors in guinea pig trachea and human bronchus.“After 6 days of culture with IL-4, human monocytes released detectable amounts of nitrite and L-citrulline that were inhibited in the presence of nitro-L-arginine (1 mM).”
“Local infusion of N-nitro-L-arginine (0.5 mM) slightly decreased basal citrulline levels in the nucleus accumbens throughout the entire period of the infusion, whereas dizocilpine maleate (50 microM) had no long-lasting effect.”
Effects of N-methyl-d
-aspartate on extracellular citrulline level in the rat nucleus accumbens“3 An inhibitor of constitutive nitric oxide synthase (NOS), Nω‐nitro‐L‐arginine (NNA) prevented the ATP‐induced increased accumulation of L‐citrulline and the relaxation effect of ATP.”
“Removal of calcium from the medium or addition of NG-nitro-L-arginine strongly inhibited both spontaneous and electrically induced production of [3H]citrulline.”
“ L-Citrulline , like L-arginine, reversed L-NNA inhibition of outward currents; only L-arginine reversed inhibition of outward currents by an antibody to argininosuccinate synthetase.”
“The synthesis of citrulline from arginine decreased by >88% in the presence of L-NNA.”
“In vivo administration of the NO synthase inhibitor L‐nitroarginine (L‐NARG; 100 μM) significantly reduced NO2‐, NO3‐ and CIT levels and prevented NMDA, kainate or KCI‐evoked increases.”
“ L-NNA (1 mM) inhibited NOS catalytic activity, assessed ex vivo using the citrulline assay , by 95 +/- 9% (P < 0.001).”
“It was also possible to show that the selective NO synthase inhibitor L-NOARG decreased the formation of citrulline.”
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