Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Citrulline and Nitric Oxide



Research Papers that Mention the Interaction

L-citrulline is known to change muscular metabolism synthesis by raising nitric oxide ( NO ) levels and increasing protein synthesis.
Trials  •  2017  |  View Paper
Citrulline decreased NO production variability by peritoneal macrophages after in vivo administration (p = 0.0034) and downregulated NO production by 22% after in vitro administration (95% CI: [6%; 35%]; p = 0.0394), without any direct effect on TNFα production.
Citrulline slightly modulates NO production in vivo and in vitro, suggesting a possible action through modulation of arginine metabolism in macrophages rather than a direct transductional effect.
Biochimie  •  2017  |  View Paper
Combination of citrulline and atorvastatin potentiated NO production in vitro.
British journal of pharmacology  •  2015  |  View Paper
The L‐arginine nitric oxide (NO) precursor, L‐citrulline , improves NO signalling and ameliorates pulmonary hypertension in newborn animals.
Acta paediatrica  •  2014  |  View Paper
CIT could also be a safe way to deliver ARG to endothelial and immune cells, and can certainly prevent excessive uncontrolled nitric oxide production.
Clinical nutrition  •  2010  |  View Paper
VIP caused an increase in l-citrulline production that was inhibited by NO in a concentration dependent manner (IC(50)~25 microM; maximal inhibition 72% at 100 microM NO).
Regulatory Peptides  •  2008  |  View Paper
Citrulline has long been administered in the treatment of inherited urea cycle disorders, and recent studies suggest that citrulline may be used to control the production of NO.
Amino Acids  •  2005  |  View Paper
Furthermore, an antiproliferative action of NO was demonstrated by an inverse correlation between the amounts of nitrite or citrulline produced in response to different stimuli (LPS/IFN-gamma or LPS/IFN-gamma with growth factors) and the level of cellular proliferation.
Proceedings of the National Academy of Sciences of the United States of America  •  1993  |  View Paper
Recent studies have shown that chronic L-citrulline supplementation increases nitric oxide synthesis, decreases blood pressure, and may increase peripheral blood flow.
Current opinion in clinical nutrition and metabolic care  •  2017  |  View Paper
Both arginine and citrulline act as NO precursors and their administration results in increased NO production and hence can potentially have therapeutic utility in MELAS syndrome.
Citrulline raises NO production to a greater extent than arginine, therefore, citrulline may have a better therapeutic effect.
The international journal of biochemistry & cell biology  •  2014  |  View Paper
Show More