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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Citrulline
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ L-citrulline is known to change muscular metabolism synthesis by raising nitric oxide ( NO ) levels and increasing protein synthesis.”
Treatment with L-citrulline in patients with post-polio syndrome: study protocol for a single-center, randomised, placebo-controlled, double-blind trial“ Citrulline decreased NO production variability by peritoneal macrophages after in vivo administration (p = 0.0034) and downregulated NO production by 22% after in vitro administration (95% CI: [6%; 35%]; p = 0.0394), without any direct effect on TNFα production.”
“ Citrulline slightly modulates NO production in vivo and in vitro, suggesting a possible action through modulation of arginine metabolism in macrophages rather than a direct transductional effect.”
“Combination of citrulline and atorvastatin potentiated NO production in vitro.”
“The L‐arginine nitric oxide (NO) precursor, L‐citrulline , improves NO signalling and ameliorates pulmonary hypertension in newborn animals.”
“ CIT could also be a safe way to deliver ARG to endothelial and immune cells, and can certainly prevent excessive uncontrolled nitric oxide production.”
“VIP caused an increase in l-citrulline production that was inhibited by NO in a concentration dependent manner (IC(50)~25 microM; maximal inhibition 72% at 100 microM NO).”
“Citrulline has long been administered in the treatment of inherited urea cycle disorders, and recent studies suggest that citrulline may be used to control the production of NO.”
“Furthermore, an antiproliferative action of NO was demonstrated by an inverse correlation between the amounts of nitrite or citrulline produced in response to different stimuli (LPS/IFN-gamma or LPS/IFN-gamma with growth factors) and the level of cellular proliferation.”
“Recent studies have shown that chronic L-citrulline supplementation increases nitric oxide synthesis, decreases blood pressure, and may increase peripheral blood flow.”
“Both arginine and citrulline act as NO precursors and their administration results in increased NO production and hence can potentially have therapeutic utility in MELAS syndrome.”
“ Citrulline raises NO production to a greater extent than arginine, therefore, citrulline may have a better therapeutic effect.”
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