Possible Interaction: Citrulline and Ng-Nitroarginine Methyl Ester

“On the other hand, attenuation effect of l-citrulline on CSD propagation velocity was prevented not only by l-NAME but also by indomethacin.”

“The effect of l-citrulline on CBF change was prevented by l-NAME , an inhibitor of NO synthase, but not by indomethacin, an inhibitor of cyclooxygenase.”

“The vasodilator response of retinal arterioles to l-citrulline was significantly diminished following treatment with N(G)-nitro-L-arginine methyl ester (30 mg/kg, i.v.),”

“ l-NAME exposure induced hypertension in the 12-week-old offspring, which CIT therapy prevented.”

“However, the protective effect mediated by L-citrulline was significantly antagonized by coadministration of L-nitroarginine methyl ester (10 mg/kg, s.c.).”

“Agmatine and l-NAME treatments significantly suppressed the increase in l-citrulline levels compared to physiological saline-treated rats in this setting.”

“The increased striatal L-citrulline concentration was blocked by NG-nitro-L-arginine methyl ester (L-NAME; 60 mg/kg), a nitric oxide synthase inhibitor, pretreatment.”

“Dialysis of 0.5 mM L-NAME into the SRF decreased Cit concentration from 340+/-40 to 180+/-20 nM (P<0.05).”

“In longitudinal smooth muscle strips, …-arginine as well as L-citrulline (10(-3) M) was capable … completely respectively partially preventing the N(G)-nitro-L-arginine methyl ester (L-NAME) (3 x 10(-5) M)-induced inhibition of electrically … nitrergic relaxations, whereas D-citrulline (10(-3) M) was not.”

“The nitric oxide synthase inhibitor N(G)-nitro-L-arginine , (100 microM) reduced [3H]L-citrulline production in preparations from all three species.”

“ Nomega-nitro-L-arginine methyl ester blocked relaxation responses and citrulline generation in both arteries.”