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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Citrulline
drug:
Methylene Blue
Research Papers that Mention the Interaction
“The administration of methylene blue (0.1 and 1 mM) via the microdialysis probe caused a dose-dependent decrease in [3H]l-citrulline efflux comparable with the effect of unselective NOS inhibitor NG-nitro-L-arginine (2 mM).”
Methylene blue inhibits hippocampal nitric oxide synthase activity in vivo“… L-citrulline … methylene blue concentrations in excess of 10(-5) M. Although the addition of methylene blue to various tissues has been reported to release superoxide anions (… blue was not affected by the presence of superoxide dismutase (100 micrograms/mL) in either cultured endothelial cells or the particulate fraction.”
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