Possible Interaction: Citrulline and Metformin

“Combined use of metformin and l-citrulline attenuated the effects obtained from their single administrations.”

“This study provides compelling evidence that metformin treatment is associated with a decrease in plasma citrulline in these patients and also in multiple tissues in diabetic mice.”

“ Citrulline was confirmed to be significantly (P < 2.96E-04) decreased at 7-year follow-up in patients who started metformin treatment.”

“Key Points Question Does treatment with l-citrulline and metformin combination therapy reduce motor function decline in ambulant patients with Duchenne muscular dystrophy?”

“Meaning Treatment with a combination of l-citrulline and metformin therapies may slow muscle function decline in a specific subgroup of patients with Duchenne muscular dystrophy, but additional clinical trials with greater statistical power are warranted.”

“Compared to its baseline serum concentration, citrulline was reduced by 17% after the first dose of metformin (p=1.34E-07) and by 24% after short-term therapy (p=2.84E-08) in the discovery study.”

“In summary, we observed an immediate and sustained reduction of serum citrulline by metformin in humans.”

“The longitudinal “human validation” study further demonstrated that the initiation of metformin treatment during the 7-year follow-up significantly reduced citrulline and increased X-21365 serum concentrations.”