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“At this time point, DFP caused significant (p<0.01) increases in biomarkers of ROS (F2-isoprostanes, F2-IsoPs; and F4-neuroprostanes, F4-NeuroPs), RNS ( citrulline ), and declines in high-energy phosphates (HEP) in rat cerebrum.”
Toxicology and applied pharmacology • 2009 | View Paper
“60 min and 15 min, respectively, before DFP injection prevented the increase in citrulline and muscle hyperactivity and the decrease in ATP and PCr.”
“Maximum increases in citrulline (272–288%) were noted 60 min after DFP injection.”
“Within 15 min of DFP exposure, with onset of fasciculations, citrulline levels were significantly elevated in all three muscles [soleus, extensor digitorum longus (EDL), and diaphragm].”