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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Citrulline
drug:
Hydrogen Peroxide
Research Papers that Mention the Interaction
“Furthermore, 100 μM H2O2 enhanced synthesis of the oxidation products, nitrite (NO) and nitrate (NO) at 12 and 36 h. iNOS protein, detected by Western blot analysis, as well as L‐citrulline levels , were also increased.”
Regulation of ICAM‐1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase“Furthermore, L-citrulline prevented inflammation (LPS) and oxidative stress ( H2O2 ) induced muscle cell wasting.”
L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism“Longer exposure to H2O2 (> or = 180 min) markedly inhibited the ionomycin-induced L-citrulline formation.”
“Although H2O2 induced only a small increase in intracellular Ca2+, it markedly increased L-citrulline formation compared with ionomycin.”
“Moreover, hydrogen peroxide increased intracellular Ca2+ concentrations, and the removal of extracellular Ca2+ reduced the hydrogen peroxide-induced formation of L-citrulline.”
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