Possible Interaction: Citrulline and Histidine

“The substitution of histidine with citruline , aspartic acid, norleucine or diaminobutyric acid in position 14 of the amino acid chain led to a considerable increase in potency, suggesting that amino acids located at this position might play a crucial role where the strength of short analogues is concerned.”

“Saturable uptake of citrulline was strongly inhibited by an excess of histidine or β-2-aminobicyclo-(2.2.1)-heptane-2-carboxylic acid; excess amounts of arginine, creatine, glutamate, cysteic acid or N-methyl-α-aminoisobutyric acid did not reduce citrulline uptake.”