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“ l-Citrulline supplementation resulted in considerable increase of the concentrations of amino acids and creatinine in the serum, and in their urinary excretion rates.”
“For all patients, AUC, CIT , Vdss, t1/2 beta and MRT were significantly correlated with creatinine clearance; the different pharmacokinetic parameters calculated showed great interindividual variations.”
“ l-citrulline also inhibited the … of BUN and creatinine induced by CsA, while, l-arginine was able to prevent the increased blood pressure and creatinine occurs after administration of … These findings suggest that the l-citrulline is more efficient than l-arginine against the adverse effects induced by cyclosporine.”