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Last Updated: 2 years ago

Possible Interaction: Citrulline and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

In cultured airway epithelial cells, L-citrulline , a precursor of L-arginine recycling and NO formation, has been shown to prevent asymmetric di-methyl arginine (ADMA)-mediated NO synthase (NOS2) uncoupling, restoring NO and reducing oxidative stress.
JCI insight  •  2019  |  View Paper
However, l-citrulline reduced plasma ADMA level and increased renal level of NO in DEX + CIT group.
Free radical research  •  2014  |  View Paper
Plasma citrulline, arginine and the ratio of arginine/asymmetric dimethylarginine ( ADMA), an endogenous inhibitor of NO synthase (arginine/ADMA ratio) were significantly increased in the L-citrulline group compared with the placebo group (p<0.05, p<0.01, p<0.05, respectively).
International journal of cardiology  •  2012  |  View Paper
L-citrulline also markedly restored the NO production, and cGMP level which was reduced by ADMA.
The increased O2.− production by ADMA was also inhibited by L-citrulline.
Scientific reports  •  2015  |  View Paper
In addition, citrulline positively correlated with ADMA (p = 0.02) levels, possibly as result of other sources of citrulline biosynthetic pathways.
Frontiers in Physiology  •  2020  |  View Paper
L-Citrulline supplementation caused a significant lowering of plasma ADMA levels.
Immunology, endocrine & metabolic agents in medicinal chemistry  •  2013  |  View Paper