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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Citrulline
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“In cultured airway epithelial cells, L-citrulline , a precursor of L-arginine recycling and NO formation, has been shown to prevent asymmetric di-methyl arginine (ADMA)-mediated NO synthase (NOS2) uncoupling, restoring NO and reducing oxidative stress.”
L-citrulline as add-on therapy to increase nitric oxide, and to improve asthma control in obese asthmatics.“However, l-citrulline reduced plasma ADMA level and increased renal level of NO in DEX + CIT group.”
“Plasma citrulline, arginine and the ratio of arginine/asymmetric dimethylarginine ( ADMA), an endogenous inhibitor of NO synthase (arginine/ADMA ratio) were significantly increased in the L-citrulline group compared with the placebo group (p<0.05, p<0.01, p<0.05, respectively).”
“ L-citrulline also markedly restored the NO production, and cGMP level which was reduced by ADMA.”
“The increased O2.− production by ADMA was also inhibited by L-citrulline.”
L-citrulline for protection of endothelial function from ADMA–induced injury in porcine coronary artery“In addition, citrulline positively correlated with ADMA (p = 0.02) levels, possibly as result of other sources of citrulline biosynthetic pathways.”
Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease“ L-Citrulline supplementation caused a significant lowering of plasma ADMA levels.”
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