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“This is indicated by urea synthesis which was never inferior in the arthritic condition when aspartate was exogenously supplied, being even higher when both aspartate and citrulline were simultaneously present.”
Molecular and Cellular Biochemistry • 2004 | View Paper
“In the presence of aspartate the rate constant for the formation of citrulline adenylate (6.2 s-1) from ATP and citrulline is 7 times faster than the rate of formation of argininosuccinate from aspartate and citrulline adenylate (0.9 s-1).”
“The protonated amino group of the bound aspartate interacts with the α-phosphate of ATP and the ureido group of citrulline , thus stimulating the adenylation of citrulline.”