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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Citicholine and Tissue Plasminogen Activator

Research Papers that Mention the Interaction

Measurement of the pool sizes of the aqueous intermediates of the CDP-choline pathway, following TPA treatment, revealed a modest decrease in the phosphocholine pool only, consistent with an activation of cytidylyltransferase.
The Journal of biological chemistry  •  1990  |  View Paper
However, patients treated with citicoline and recombinant tissue-plasminogen activator ( rt-PA ) showed a higher EPC increment compared to patients treated only with citicoline or non-treated (35·4±15·9 versus 8·4±8·1 versus 0·9±10·2 CFU-EC, P<0·0001).
Neurological research  •  2011  |  View Paper
The incorporation of choline and phosphocholine but not CDP-choline was enhanced in nuclei of TPA treated cells.
Neurochemical Research  •  2004  |  View Paper
CONCLUSIONS These results demonstrate that the combination of low-dose ci icoline an d rtP A si gnificantly reduced infarct size in this focal ischemia model.
Citicoline 500 mg/kg and citicoline combined with rtPA also promoted functional recovery.
Stroke  •  1999  |  View Paper