supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Citicholine
Research Papers that Mention the Interaction
“Measurement of the pool sizes of the aqueous intermediates of the CDP-choline pathway, following TPA treatment, revealed a modest decrease in the phosphocholine pool only, consistent with an activation of cytidylyltransferase.”
Phosphorylation of CTP:phosphocholine cytidylyltransferase in vivo. Lack of effect of phorbol ester treatment in HeLa cells.“However, patients treated with citicoline and recombinant tissue-plasminogen activator ( rt-PA ) showed a higher EPC increment compared to patients treated only with citicoline or non-treated (35·4±15·9 versus 8·4±8·1 versus 0·9±10·2 CFU-EC, P<0·0001).”
“The incorporation of choline and phosphocholine but not CDP-choline was enhanced in nuclei of TPA treated cells.”
“CONCLUSIONS These results demonstrate that the combination of low-dose ci icoline an d rtP A si gnificantly reduced infarct size in this focal ischemia model.”
“Citicoline 500 mg/kg and citicoline combined with rtPA also promoted functional recovery.”
Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback