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Last Updated: 3 months ago

Possible Interaction: Citalopram and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

Participants treated with citalopram had higher cocaine abstinence rates compared to placebo-treated participants.
Journal of addictive diseases  •  2009  |  View Paper
Pretreatment with the kappa agonists enadoline (0.01 mg/kg) and spiradoline (0.3 mg/kg) or the 5-HT transport inhibitors fluoxetine (5.6 mg/kg) and citalopram (10.0 mg/kg) attenuated the priming effects of cocaine , shifting the cocaine dose–response function rightward and downward.
Psychopharmacology  •  2009  |  View Paper
Citalopram alone produced predominantly saline-appropriate responding, but when administered before cocaine, citalopram dose-dependently shifted the cocaine dose-response curve leftward.
Citalopram , however, attenuated the discriminative-stimulus effects of cocaine in squirrel monkeys trained to discriminate cocaine from saline, though it enhanced the discriminative-stimulus effects of a low dose of cocaine in rats trained to discriminate high and low doses of the drug.
Behavioural pharmacology  •  2009  |  View Paper
Pretreatment with citalopram attenuated the discriminative stimulus effects of cocaine and produced an overall rightward shift in the cocaine dose-response function, whereas pretreatment with GBR 12909 produced an overall leftward shift in the cocaine dose-response function.
Pretreatment with citalopram or fluoxetine attenuated the rate-increasing effects of cocaine and produced an overall downward shift in the cocaine dose-response function.
Psychopharmacology  •  2005  |  View Paper