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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Citalopram
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“In an effort to characterize the oral citalopram challenge, we hypothesized that oral racemic citalopram would increase plasma cortisol, prolactin and adrenocorticotropic hormone (ACTH) concentrations; ACTH had not been measured in previous studies on the neuroendocrine effects of citalopram.”
Effects of oral racemic citalopram on neuroendocrine responses“ ACTH and PRL secretion was higher during citalopram infusion compared to placebo (p<0.05) in both groups, while cortisol secretion was higher during citalopram infusion only in healthy controls (p<0.05), but not in anorexic patients.”
“ ACTH significantly increased plasma corticosterone levels in both control and citalopram treated rats over a period of 120 min.”
Chronic citalopram treatment does not sensitize the adrenal gland to ACTH (1—24) in rats“We have demonstrated that a single injection of citalopram is able to prolong acute restraint-induced increases in plasma levels of corticosterone and adrenocorticotrophin (ACTH).”
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