Possible Interaction: Cisplatin and Vitamin D

“ Vitamin D also promotes the therapeutic effect of CDDP.”

“Our study reveals that vitamin D can enhance cisplatin chemotherapy and suggests that vitamin D should be supplied during chemotherapy; however, more follow-up clinical studies are needed.”

“We found that vitamin D sensitised oral cancer cells to cisplatin and partially reversed cisplatin resistance.”

“This study presents data indicating that … of the hormonally active form of vitamin D , 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], its non-calcemic analogues 20S-hydroxyvitamin D3 and 21-…, as well as the low-calcemic synthetic analog calcipotriol, modulate the efficacy of the anticancer drugs cisplatin and ….”

“Furthermore, our data suggest that treatment with low calcemic vitamin D analogues or the maintenance of optimal level of vitamin D by proper supplementation, can enhance the anticancer efficacy of cisplatin.”

“The combined use of vitamin D and dichlorodiammine-platinum(II) (DDP) significantly increased the inhibition rate on A549 cell proliferation, which peaked after culturing for 96 h (Table 4).”

“ Vitamin D has the capability to inhibit the proliferation of lung adenocarcinoma cells, synergistically inhibit the proliferation of lung adenocarcinoma cells with DDP , and when capsulated with nanomaterial can significantly inhibit the proliferation of lung adenocarcinoma cells.”

“Moreover, vitamin‐D3 supplementation with either cisplatin forms lead to a further decrease of all markers, markedly with cisplatin nanoparticles.”