Possible Interaction: Cisplatin and Vitamin C

“Moreover, AA worked synergistically with chemotherapeutic agent cisplatin to impair CC cells growth both in vitro and in vivo.”

“ l-Ascorbic acid only partially nullifies the gonadotoxic effects of cisplatin.”

“Further findings showed that the combined dose of vitamin C and cisplatin could increase the percentage of apoptotic and necrotic cells in comparison with a single dose of cisplatin.”

“Results: Co-treatment of gastric cancer cells with vitamin C in its IC50 dose in addition to cisplatin in both IC50 (10 µg/ml) and five times less (2 µg/ml) doses could increase the cytotoxicity effect of cisplatin in a synergistic manner.”

“A combination of vitamin C with 5-Fu or cisplatin exerted a significantly enhanced cytotoxic effect compared to both drugs individually.”

“Our data demonstrate that vitamin C enhances the antitumor activity of 5-Fu and cisplatin , in part by inhibiting translocation of NF-κB and AP-1, and sensitizes cancer cells to drug-induced cell death.”

“Pretreatment with vitamin C inhibited 5-Fu or cisplatin induced NF-κB nuclear translocation and DNA binding activity, but vitamin C had no effect on IκB-α protein levels.”

“Also, Vitamin C reduced cell toxicity of cisplatin during simultaneous treatment.”

“The results of treatments with Vitamin C indicated that it statistically significantly decreases the number of chromosome aberrations and number of metaphases with aberrations induced with cisplatin , but it can not completely protect cells from damage.”

“The test concentrations of Vitamin C (10 and 100 microg/ml) had a limited antimutagen effect on cisplatin (0.5 microg/ml), which can cause genetic damage through free radical mechanisms.”

“In the present work the ability of vitamin C to modulate cytotoxic and genotoxic effects of a cisplatin analog, conjugate (NH3)2Pt(SeO3), in terms of cell viability, DNA damage and repair in human lymphocytes was examined using the trypan blue exclusion test and the alkaline comet assay, respectively.”

“In conclusion, both allicin and AA showed significant nephroprotective effects against CDDP intoxication and their combination exhibited better protection than either agent alone.”

“However, l-carnitine, vitamin C , or their combination significantly attenuated the alterations caused by CIS in the plasma and kidneys of the rats.”

“However, the administration of both vitamin C and l-carnitine, and not either of the two showed additive effects in attenuating the adverse effects of cisplatin.”

“The administration of Cis (5mg/kg/week for 5 consecutive weeks) resulted in a decline in the concentrations of reduced glutathione and ascorbic acid.”