Possible Interaction: Cisplatin and Tyrosine

“These results demonstrate that the phosphorylation of tyrosine 332 by Src modulates the cleavage of PKCdelta and the sensitivity of glioma cells to TRAIL and cisplatin.”

“In leukemia cells expressing high level of TEL-JAK2 fusion protein, cisplatin dramatically inhibited tyrosine phosphorylation of TEL-JAK2 as well.”

“In ovarian cancer and sarcoma cells that express constitutively active JAK2, cisplatin significantly inhibited tyrosine phosphorylation and kinase activity of JAK2 in a dose- and time-dependent manner.”

“Meanwhile, cisplatin also inhibited Stat3 tyrosine phosphorylation and down-regulated BcL-XL anti-apoptotic protein in the cancer cells tested.”

“5-FU and CDDP inhibited tyrosine phosphorylation of 83-kDa and 115-kDa proteins, however 137Cs did not inhibit their phosphorylation and PLM enhanced the tyrosine phosphorylation.”

“ CDDP + AS IV co-treatment significantly altered two pathways in … metabolism), five pathways in the urine (phenylalanine metabolism; phenylalanine, tyrosine , and tryptophan biosynthesis; arginine biosynthesis; arginine and proline metabolism; and histidine metabolism), and five pathways … and dicarboxylate metabolism; arginine and proline metabolism; and D-glutamine and D-glutamate metabolism).”

“Taken together, these data suggest that tyrosine phosphorylation play a critical regulatory role in the activation of macrophages with CP.”

“We found that cisplatin increased tyrosine phosphorylation of several proteins in peritoneal macrophages and in P388D1 and IC-21 macrophage cell lines.”