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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In vitro growth inhibition and apoptosis effects of cisplatin were differential and inversely associated with those of retinoic acid and especially IFNalpha in two skin SCC lines.”
Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancer.“Pretreatment with differentiating agent all-trans retinoic acid counteracts cisplatin resistance specifically of the slowly dividing compartment indicating effect on CD133+/CXCR4+ cells.”
“The combinatorial treatment of ATRA acid and cisplatin reduced protein kinase B (AKT) (Thr308) phosphorylation, and promoted apoptosis of HCC cells more significantly than treatment with cisplatin alone.”
“Furthermore, ATRA treatment augmented the chemosensitising effects of cisplatin.”
“In conclusion, ATRA may be potentially valuable in treatment of HNSC CSC, especially in combination with cisplatin.”
“ConclusionThese results suggest that retinoids not only exhibit antimetastatic effect, but also enhance the antitumor activity of cisplatin in vivo.”
“Pretreatment with retinoids increased the sensitivity to CDDP but not to 5-FU in in-vitro.”
“In contrast, the association of the two retinoids together with cisplatin did not produce any benefit and resulted in increased toxicity.”
“In the same tumour model, 4-HPR and RA separately increased cisplatin activity, even though for RA the increase was not statistically significant.”
“CONCLUSIONS AT A si gnificantly enhanced the antitumor effect of cis platin in cervical cancer cells, the mechanism of which might be attributed to its effect of inducing the differentiation of cancer stem-like cells.”
“Furthermore, there was an indication that the combination of ATRA with 5FU and CDDP caused an increase in cell cycle arrest in G2/M and G0/G1.”
“We conclude that low concentration of ATRA enhances the cytotoxicity of CDDP and 5FU by facilitating apoptosis and cell cycle arrest in gastrointestinal CSCs and provide a rational basis for the design of novel, well-tolerated CDDP- and 5FU-based chemotherapy in human gastrointestinal carcinoma.”
“Strong antagonisms were also obtained with ATRA and fotemustine or cisplatin in both cell lines.”
“When ATRA was used in combination with cisplatin , the resulting synergistic effects were robust and significant.”
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