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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
Thiamine Pyrophosphate
Research Papers that Mention the Interaction
“ TPP seems to have a preventive effect on oxidative stress in the liver caused by cisplatin.”
The Effect of Thiamine and Thiamine Pyrophosphate on Oxidative Liver Damage Induced in Rats with Cisplatin“Conversion of thiamine to TPP significantly decreased in the CIS group.”
“Increased production of IL-1β and MDA by cisplatin was inhibited by TPP , while it was not inhibited by thiamine.”
“These results indicate that cisplatin inhibits the formation of TPP from thiamine, leading to severe PNP.”
The effect of thiamine and its metabolites on peripheral neuropathic pain induced by cisplatin in rats“However, infertility caused by cisplatin was only prevented and treated by TPP.”
“ TPP , especially at a dosage of 20 mg/kg, significantly reduced TBARS and MPO levels that increase with cisplatin administration compared with the thiamine group, while TPP significantly increases GSH and SOD levels.”
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